New homologues and metabolites of chemicals: stimulants, dissociatives, benzodiazepines, sedatives, tranquilizers, opioids, analgesics, tryptamines, psychedelics, indazoles, benzazoles
Articles about chemicals, news in the world of chemistry, news about new chemical developments, articles about new homologues, news about metabolites
Psychedelic; phosphorylated psilocin derivative; indole derivative of tryptamine. Psilocin and psilocybin are solids that decompose when heated near the melting point. Psilocybin melts at 173-176C. They are found in mushrooms of the genus psilocybe. It was first isolated in its pure form in 1958 by Albert Hofmann.z The effects of psilocybin are comparable to aRead More
Psychostimulants increase mood, the ability to perceive external stimuli, and psychomotor reactivity. They stimulate intellectual activity, speeding up the processes of thinking, which is often accompanied by the elimination of fatigue, drowsiness, and the suppression of hunger. Classification: According to the chemical structure of I. Phenylalkylamines: phenamine (amphetamine). II. Sydnonymine derivatives: sydnocarb (mesocarb), sydnophen (pheprosidsidnimine).Read More
Piperidine is one of the most common heterocycles, and its derivatives are found in a variety of pharmacological groups, including among neurotropic agents. These compounds are numerous among analgesics, and in addition to the “classic” promedol, fentanyl and its derivatives, the paper presents the results of studies of new compounds with analgesic activity and aRead More
There are a number of non-competitive NMDA receptor inhibitors acting on the phencyclidine site located in the ion channel, which act on receptors only in the presence of agonists. It follows that the mechanism of their action is to block the open ion channel. Phencyclidine is a highly affinity NMDA receptor antagonist. Modification of theRead More
Cathinones is a narcotic substance that can be obtained from an evergreen plant of the Berescletaceae family. Kata leaves are grown mainly in the Arabian Peninsula and in the Northeastern part of Africa. The narcotic effect is achieved by chewing fresh shoots or drinking their decoction. The narcotic effect of cathinone lasts for several hours.Read More
The Dutch Senate has approved a bill banning hundreds of types of so-called designer drugs. The law came into force on July 1. According to the NRC newspaper, until now, manufacturers of designer drugs have managed to circumvent the law and bring a narcotic substance to the market, only slightly changing its composition so thatRead More
This group consists of chemical compounds that, being antagonists of NMDA receptors, interfere with the signaling relationships of various parts of the brain. The resulting dissociation of internal and external signals is due to the uncompetitive blocking of the effects of glutamic acid, more precisely glutamate anions, which are the main excitatory neurotransmitter for ionotropicRead More
Benzodiazepines – a list of drugs and their effects. What to do in case of poisoning and intoxication? What is the most effective antidote? We will talk about the narcotic effect of benzodiazepines, as well as analyze the mechanism of action of the drugs. This is the name of a group of psychotropic drugs thatRead More
Antidepressants combine a large group of drugs, the main property of which is the elimination of a depressive state. Antidepressants include MAO inhibitors: hydrazine (iprazide, nialamide) and nonhydrazine derivatives (indopan, etc.), 4- and 3-cyclic compounds (mianserin, imipramine, amitriptyline, azafen, pyrazidol), secondary amines (desipramine). There is also a group of antidepressants of the second generation (nomifenzyl,Read More
Neuroleptics – drugs for the treatment of mental disorders Neuroleptics are representatives of a large class of psychotropic drugs. The latter have a selective effect on the human psyche, i.e. on his thinking and emotions. Neuroleptics, in turn, slow down neuropsychiatric processes and calm a person. However, if these antipsychotic drugs are prescribed to aRead More