Rated 4.25 out of 5 based on 4 customer ratings
(4 customer reviews)


O-Desmethyltramadol (other names: Desmetramadol, O-DSMT) is an opioid substance belonging to the class of phenylpropylamine, a metabolite of tramadol, which has analgesic properties several times more active than tramadol.

You can buy O-DSMT online at a price:

QUANTITY Disc (%) Price per gram
1 g
2 g 18 % $22
5 g 31 % $18
10 g 47 % $15
25 g 68 % $11.50
50 g 76 % $6.90
100 g 78 % $4.80
250 g 79 % $4.50
500 g 80 % $4.20
1000 g 82 % $3.90


O-Desmethyltramadol (other names: Desmetramadol, O-DSMT, Mono-O-demethyltramadol) is an opioid substance belonging to the class of phenylpropylamine, a metabolite of tramadol, which has analgesic properties several times more active than tramadol.


The use of O-DSMT as a research designer substance was first mentioned in the 2010s.


(+/-)O-Desmethyltramadol is an atypical synthetic opioid, it contains two rings, it is a cyclohexane ring, it is connected to the R1 phenyl ring, substituted by R3 hydroxy group which is where and the cyclohexane ring is connected to the phenyl ring, it is connected to the dimethylamine group connected by a methyl bridge, has a substituent on the R2 cyclohexane ring.

O-Desmethyltramadol is produced as a racemate of its two isomers changing the direction of R2 and R1 bonds results in R- and S-enantiomers. The difference between O-DMST and tramadol is that there is no methyl group in the R3 methoxy substituent.


This substance is relatively new and the pharmacological and toxicological properties are not well understood; the following is a summary of chemical studies and tests performed in rats.

O-DMST is an active μ-opioid agonist, more potent than the parent compound (tramadol), and is also a high-affinity ligand of δ- and κ-opioid receptors, unlike tramadol.

The (-)-O-DSMT enantiomer acts as an inhibitor of norepinephrine reuptake. Activation of μ-opioid receptors mimics endogenous endorphins, resulting in analgesia, euphoria, and anxiolytic effects.

The dosage of the drug
(According to the information on the Internet)

Threshold 5 mg
Light 10 – 25 mg
Common 25 – 50 mg
Strong 50 – 80 mg
Heavy 80 mg +

Total 5 – 10 hours
Onset 20 – 40 minutes
Peak 2 – 5 hours
Offset 2 – 4 hours
After effects 1 – 3 hours

Tolerance to the drug may develop with repeated, regular use of the drug.

Legal status

UK: O-DMST is a controlled substance.
Germany: O-DMST is illegal for sale for human use.
Sweden: O-DMST is a controlled substance.

Technical Information:

Product Name: O-DSMT

Other Name(s): O-Desmethyltramadol,  Desmetramadol

IUPAC Name: 3-[(1R,2R)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]phenol

CAS: 80456-81-1, 144830-14-8

Molar Mass: 249.35 g/mol

Molecular Formula: C15H23NO2

InChi Code: InChI=1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1



Formulation: A crystalline solid



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4 reviews for O-DSMT

  1. Rated 4 out of 5


    I have my own private laboratory in Newport Beach, California, USA. I want to order delivery of O-DSMT 100 g for research. When buying, do you necessarily need some documents?

    • admin

      We have sent you the detailed terms of purchase to your email address.

  2. Rated 4 out of 5

    Eckerd Bodden

    Wird das o-dsmt-Paket von Ihnen nach Deutschland kommen? Danke

    • admin

      Wir haben Ihnen eine detaillierte Antwort auf Ihre E-Mail geschickt, die Sie im Kommentar angegeben haben. Wenn Sie irgendwelche Fragen haben, schreiben Sie uns bitte an unsere Kontakt-E-Mail. Danke.

  3. Rated 4 out of 5

    Dillen Micheau

    I sent you an order in the name of Dillen Micheau, but I did not receive any payment information, it says crypto payment. What is your Bitcoin address? How to pay?

    • admin

      The payment information has been re-sent to you, check it out, if you do not see the details of your order on your email, then contact us via the website in the contacts section.
      Thank you.

  4. Rated 5 out of 5


    I would like to buy, but there are a few questions about delivery before buying, write to me, I will be glad to hear from you.

    • admin

      We have contacted you by e-mail and are waiting for your reply, please reply.

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