L-838,417
$22.00
L-838,417 (other names: L-838417) is an anxiolytic drug developed by Merck, Sharp and Dohme, classified as a non-benzodiazepine, but with similar effects.
L-838,417 acts on GABA receptors with an allosteric modulator and acts as a partial agonist in α2, α3, α5 and acts as a negative allosteric modulator in α1 and with little affinity for α4 or α6.This explains the anxiolytic effects, and can also cause a sedative effect, however, in animal studies, sedative effects were not detected even at high doses.
You can buy L-838,417 online at a price:
| QUANTITY | Disc (%) | Price per gram |
| 1 g | – | – |
| 2 g | 00 % | $22.00 |
| 5 g | 18 % | $18.00 |
| 10 g | 36 % | $14.00 |
| 25 g | 54 % | $10.00 |
| 50 g | 68 % | $7.00 |
| 100 g | 75 % | $5.50 |
| 250 g | 77 % | $4.90 |
| 500 g | 80 % | $4.30 |
| 1000 g | 81% | $4.00 |
Description
L-838,417 (other names: L-838417) is an anxiolytic drug developed by Merck, Sharp and Dohme, classified as a non-benzodiazepine, but with similar effects.
Pharmacology
L-838,417 acts on GABA receptors with an allosteric modulator and acts as a partial agonist in α2, α3, α5 and acts as a negative allosteric modulator in α1 and with little affinity for α4 or α6.This explains the anxiolytic effects, and can also cause a sedative effect, however, in animal studies, sedative effects were not detected even at high doses.
The synthesis of this substance was described in 2005 in the Journal of Medicinal Chemistry.
It has also been found in animal studies that when exposed to the drug L-838,417, potassium chloride cotranspoter 2 (KCC2) stabilizes on the membranes of neurons, which leads to an analgesic effect.
Technical Information:
Product Name: L-838,417
Other Name(s): L-838417
IUPAC Name: 7-tert-butyl-3-(2,5-difluorophenyl)-6-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-[1,2,4]triazolo[4,3-b]pyridazine
CAS: 286456-42-6
Molar Mass: 399.4 g/mol
Molecular Formula: C19H19F2N7O
InChi Code: InChI=1S/C19H19F2N7O/c1-19(2,3)13-8-15-24-25-17(12-7-11(20)5-6-14(12)21)28(15)26-18(13)29-9-16-22-10-23-27(16)4/h5-8,10H,9H2,1-4H3
InChIKey: BQDUNOMMYOKHEP-UHFFFAOYSA-N
Canonical SMILES: CC(C)(C)C1=CC2=NN=C(N2N=C1OCC3=NC=NN3C)C4=C(C=CC(=C4)F)F
Formulation: A crystalline solid
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