PIPERIDINE DERIVATIVES
Piperidine is one of the most common heterocycles, and its derivatives are found in a variety of pharmacological groups, including among neurotropic agents. These compounds are numerous among analgesics, and in addition to the “classic” promedol, fentanyl and its derivatives, the paper presents the results of studies of new compounds with analgesic activity and a piperidine cycle. Reviews of piperidine antipsychotics such as haloperidol and risperidone are reviewed, and new compounds demonstrating antipsychotic activity through their effects on dopamine and serotonin receptors are highlighted. The data on the effect of methylphenidate on the brain in attention deficit hyperactivity disorder (ADHD) have been analyzed, which help to understand the disorders occurring in this disease. Tiagabine is considered as an antiepileptic drug that reduces the number of seizures in resistant forms of partial epilepsy, as well as reduces microglial activation and may be effective in neurodegenerative diseases. The last section is devoted to drugs for the treatment of Alzheimer’s disease (AD), namely donepezil, its modifications and some new compounds potentially capable of inhibiting the progression of AD through inhibition of Aß42 protein synthesis.
About Author
